Last edited by Sajar
Thursday, April 16, 2020 | History

2 edition of Mathematical models of metabolic regulation found in the catalog.

Mathematical models of metabolic regulation

  • 205 Want to read
  • 9 Currently reading

Published by Akadémiai Kiadó in Budapest .
Written in English

    Subjects:
  • Metabolism -- Regulation -- Mathematical models.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by T. Keleti and S. Lakatos.
    SeriesSymposia biologica Hungarica ;, vol. 18
    ContributionsKeleti, T., Lakatos, Sándor.
    Classifications
    LC ClassificationsQP171 .M363
    The Physical Object
    Pagination259 p. :
    Number of Pages259
    ID Numbers
    Open LibraryOL4606873M
    ISBN 109630509199
    LC Control Number77370200

    Mathematical modelling of glucose-insulin system is very important in medicine as a necessary tool to understand the homeostatic control of human body. It can also be used to design clinical trials and in the evaluation of the diabetes prevention. In the last three decades so much work has been done in this direction. One of the most notable models is the global six compartment-mathematical Author: Jean Marie Ntaganda, Froduald Minani, Wellars Banzi, Lydie Mpinganzima, Japhet Niyobuhungiro, Jean B. nasacontractor nasa cr report ici ih c a mathematical model of physiological temperature regulation in man by j, a, j, stolwgk prepared by yale university school of medicine new haven, conn. for utlcs and space administratio, yashington, d. c. august Feb 04,  · tational models have represented the detailed chemical composition of the body (33, 38). ENERGY BALANCE Most mathematical models of human energy regulation make the assumption that weight change is solely determined by an imbalance between dietary energy intake and the energy expended by the body to maintain life and per-form physical work. The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published mathematical model of mouse metabolism to describe changes in body weight and body composition in rats in response to two short-term interventions Cited by: 4.


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Mathematical models of metabolic regulation Download PDF EPUB FB2

The Mathematical Modeling of Metabolic and Endocrine Systems: Model Formulation, Identification, and Validation (Applied Mathematics Series) 1st Edition. by Ewart R. Carson (Author) › Visit Amazon's Ewart R.

Carson Page. Find all the books, read about the author, and more. Author: Ewart R. Carson. Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.

May 10,  · Metabolic Pathways, Third Edition, Volume V: Metabolic Regulation presents the regulation of metabolism in terms of the control of protein synthesis.

This book discusses the significance of the control of metabolism in regard to the remarkable mechanisms involved and to the provision of an effective conceptual framework for appreciating the Book Edition: 3.

Cell Metabolism Article A Mathematical Model of Murine Metabolic Regulation by Leptin: Energy Balance and Defense of a Stable Body Weight Joshua Tam,1,2 Dai Fukumura,1 and Rakesh K.

Jain1,* 1Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MAUSA. Metabolic regulation and mathematical models. Author links open overlay panel R.

Heinrich S.M. Rapoport T.A. Rapoport. Show moreCited by: Publisher Summary This chapter discusses the study of the regulation of metabolism by mathematical models. There has grown a sizable literature on the theoretical analysis of biological regulation, mostly by means of mathematical models.

Modeling is an advanced technique for the study of the lowdowntracks4impact.com by: In this ap- proach a mathematical model of the metabolic systems is first constructed; then the nature of the model is evaluated using simulation techniques to interpret the overall behavior of Author: Christoph Giersch.

Dynamic mathematical models of metabolic networks While flux analysis provides a descriptive snap-shot of physiology, clearly, it’s role in the rational design or reengineering of metabolism is limited by its inability to address the dynamic evolution of the lowdowntracks4impact.com by: Apr 01,  · In this review, we focus on mathematical models that describe the cellular metabolism, as these models play a central role in the rapid developing field of metabolic engineering 3, 4.

In our discussion, we group the models according to their structure: firstly, stoichiometric models, which are based on the time invariant characteristics of metabolic networks; and secondly, kinetic models, Cited by: 8 Mathematical Models of Dopamine Metabolism in Parkinson’s Disease experiment al observat ions of the biochemi cal, pharmaco logical, and el ectrophysi o- logical feat ures of the syst em).

Mathematical Modelling of Metabolic Regulation in Aging Mark T. Mc Auley, 1, * Kathleen M. Mooney, 2 Peter J. Angell, 3 and Stephen J. Wilkinson 1 Christoph Kaleta, Academic EditorCited by: Mathematical modeling of metabolism is a powerful techniques for gaining sufficient quantitative understanding of complex metabolic pathways [, ] in order to alter Mathematical models of metabolic regulation book distribution of.

Mar 27,  · The model-based integration of signal transduction, regulation, and metabolism is still not standard and most models are restricted to describing either metabolic processes, signal transduction or regulation (Gonçalves et al., ).

The response of cellular metabolism to oxygen was studied previously using mathematical lowdowntracks4impact.com by: Mathematical model of galactose regulation and metabolic consumption in yeast Author links open overlay panel Tina M.

Mitre a Michael C. Mackey a b c Mathematical models of metabolic regulation book Khadra a b c Show moreCited by: 1. A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to oxygen. Michael Ederer. 1 *, Sonja Steinsiek. 2,StefanStagge.

2, Matthew D. Rolfe. The final model is able to provide an integrated description of metabolic fluxes and concentrations, gene expression levels and genetic regulation. A further hallmark of the model is that the balances of the metabolites ATP, ADP, and AMP, as well as NADH, NAD, NADPH, and NADP are explicitly lowdowntracks4impact.com by: Jan 07,  · A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight Joshua Tam, 1, 2 Dai Fukumura, 1 and Rakesh K.

Jain 1, # 1 Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Cited by: Mathematical modeling of the metabolism and body weight regulation is an important and growing subfield of obesity research which serves to understand these mechanisms.

Models aid in understanding changes in body composition during weight loss or gain, the degree of individual adherence to a diet or exercise plan, and long‐term effects of changes in diet and exercise on an individual’s weight.

Mar 02,  · A dynamical model of phosphoinositide metabolism was designed within the framework of Biochemical Systems Theory (BST) 24,37,38,39,40,41, using ordinary differential equations (ODEs) in Cited by: 5.

Books by Language Additional Collections. Featured movies All video latest This Just In Prelinger Archives Democracy Now. Occupy Wall Street TV NSA Clip Library.

TV News. Top Animation & Cartoons Arts & Music Computers & Technology Cultural & Academic Films Ephemeral Films Movies News &. Dec 22,  · A mathematical model of energy metabolism based on flux balance, the minimization of nutrient utilization together with the macromolecular capacity constraint, is sufficient to explain the Warburg effect [ 41 ].

At low energy demands, the macromolecular capacity is irrelevant and energy is generated from OxPhos, Cited by: The main focus of mathematical modeling is the regulation of glucose uptake within the time range of minutes up to few hours.

Consequently, the models either completely neglect the synthesis and. Mathematical Modelling in Systems Biology: An Introduction Brian Ingalls to be extended to mechanistic mathematical models.

These models serve as working hypotheses: that interested researchers at all levels will find the book useful for self-study. The mathematical prerequisite for this text is a working knowledge of the derivative.

Regulation is modeled by phenomenological laws describing the activation or repression of enzymes and genes in dependence of metabolic signals. The model is intended to describe the behavior of E. coli in a chemostat culture in depedence on the oxygen supply.

Computational Modeling of Metabolic Control. Metabolomics is a systems biology look at the interactions of metabolic pathways within an organism.

Computational tools are useful and necessary to model these complex interactions and predict outcomes of perturbations of the system. From an aging perspective, several other models are worth mentioning; for example, the FBA model of mitochondrial energy metabolism by Ramakrishna and colleagues.

This model was used to characterize the optimal flux distributions for maximal ATP production in the lowdowntracks4impact.com by: In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model.

Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and. Jul 01,  · The validation process is an essential component of the modelling ofin vivo endocrine and metabolic systems.

In the paper a validation study of a comprehensive model of the glucose regulation system, previously developed for intravenous testing, is performed on a new data set based on oral glucose tolerance lowdowntracks4impact.com by: A mathematical model of liver metabolism: from steady state to dynamic.

D Calvetti 1, A Kuceyeski 1 and E Somersalo 2 In silico mathematical models that can adequately describe metabolite Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling J.

Schleicher et al Biochimica et. Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not.

Mathematical modeling of human energy regulation and body weight change has recently reached the level of sophistication required for accurate predictions. Mathematical models are beginning to provide a quantitative framework for integrating experimental data in humans and thereby help us better understand the dynamic imbalances of energy and macronutrients that give rise to changes in body Cited by: Biochemical and metabolic interpretation of microbial growth is an important topic in bioreactor design.

We intend to address valuable information about the relation of critical operation variables and the simulation of bioprocesses with unstructured and structured kinetic models. Process parameters such as nutrient supply, pH, dissolved oxygen, and metabolic end-products directly impact the Cited by: 1.

A mathematical model of physiological temperature regulation in man, Volume NASA contractor report A Mathematical Model of Physiological Temperature Regulation in Man, Yale University. Dept. of Epidemiology and Public Health: Authors: Jan A. Stolwijk. Modelling biological systems is a significant task of systems biology and mathematical biology.

[a] Computational systems biology [b] [1] aims to develop and use efficient algorithms, data structures, visualization and communication tools with the goal of computer modelling of biological systems.

Jul 02,  · Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock Alessandro Furlan, Marine Jacquier, Aurore Woller, Laurent Héliot, Hélène Duez, Bart Staels, and View ORCID Profile Marc LefrancCited by: 2.

Feb 09,  · In conclusion, our mathematical model includes not only enzyme kinetics and their allosteric regulation but also spatial compartmentalization of the rate-limiting enzymes of the pathway, thus allowing us to understand the metabolic contributions of glucose flux at both single-cell and population levels.

Reinhart Heinrich (24 April – 23 October ) was a German biophysicist. He was professor at the Humboldt University of Berlin, and best known as a founder of metabolic control theory.

Among his services to the scientific community, Reinhart was associate editor of PLoS Computational lowdowntracks4impact.com mater: Dresden University of Technology. Apr 01,  · Through examples from the metabolic, stress, and reproductive axes, we illustrate how models can provide insight on dynamic hormone regulation spanning several spatiotemporal scales and the key role that these quantitative models could play in the advancement of chronomedicine.

Rather than present the vast and diverse array of mathematical Cited by: 3. regulation, metabolic networks, signal transduction and mechanical networks.

To integrate the large amount of data produced by these networks, it is essential to develop mathematical models to simulate such complex biological systems.

We have previously described a mathematical model tool for complex enzyme mechanism. We also discuss the methods by which mathematical models of metabolism are built and integrated with gene expression data to generate hypotheses about global metabolic network function.

Finally, we explore genetics studies of C. elegans that have shed light on metabolic network regulation and function, with emphasis on dissecting the metabolic. Mathematical model of galactose regulation and metabolic consumption in yeast.

@article{MitreMathematicalMO, title={Mathematical model of galactose regulation and metabolic consumption in yeast.}, author={Tina Maria Mitre and Michael C. Mackey and Anmar Khadra}, journal={Journal of theoretical biology}, year={}, volume={}, pages.Mathematical and theoretical biology is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to prove and validate the scientific theories.Purpose: This study uses a theoretical model to investigate the response of retinal blood ow to changes in tissue oxygen demand.

The study is motivated by the need for a better understanding of metabolic ow regulation mechanisms in health and disease.

Methods: A mathematical model is used to calculate retinal blood ow for di erent levels.